Endoscopic Sinus Surgery: Proven Effective Treatment for Chronic Sinus Problems

The MACRO study, a large UK clinical trial published in the Lancet, has provided strong evidence that endoscopic sinus surgery (ESS) is an effective treatment for adults with chronic rhinosinusitis (CRS) — persistent inflammation of the sinuses that causes nasal blockage, facial pressure, and reduced quality of life.

The trial compared surgery with medical treatments, including three months of antibiotic therapy and standard intranasal medications (nasal sprays and rinses). Over 500 patients were involved across 20 hospitals.

Results of the Endoscopic Sinus Surgery trial

Results showed that patients who underwent endoscopic sinus surgery experienced significantly greater improvements in sinus symptoms and quality of life than those who received only medication. In contrast, long-term antibiotic treatment did not offer meaningful benefits.

These findings confirm that endoscopic sinus surgery is a safe and effective option for patients whose symptoms persist despite medical therapy. For many people living with chronic sinus problems, surgery can restore nasal function, improve breathing, reduce infections, and enhance overall wellbeing.

Arrange a sinus surgery consultation

If you have ongoing sinus symptoms that have not improved with medication, our ENT specialists can discuss whether endoscopic sinus surgery is suitable for you.